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Avelox tissue penetration

Michael C. Moxifloxacin, the newest fourth-generation fluoroquinolone, has a broad spectrum of antibacterial activity covering both Gram-positive and Gram-negative aerobic and anaerobic bacteria and is therefore very well suited for the treatment of biliary tract infections. The present study aimed to determine the penetration of moxifloxacin into gallbladder tissue to evaluate its antibiotic potential in this indication. Hospitalized patients with acute cholecystitis received a single, 1 h infusion of mg of moxifloxacin before cholecystectomy. Serum and gallbladder wall tissue samples were collected during surgery, and the moxifloxacin concentrations were measured by HPLC. Sixteen patients eight men and eight women were included between January and April
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Moxifloxacin - Wikipedia

Moxifloxacin , sold under the brandname Avelox among others, is an antibiotic used to treat a number of bacterial infections. Common side effects include diarrhea , dizziness, and headache. Moxifloxacin was patented in and approved for use in the United States in Moxifloxacin is used to treat a number of infections, including: respiratory tract infections , cellulitis , anthrax , intra-abdominal infections, endocarditis , meningitis , and tuberculosis. In the United States, moxifloxacin is licensed for the treatment of acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, community acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and complicated intra-abdominal infections. Based on its investigation into reports of rare but severe cases of liver toxicity and skin reactions, the European Medicines Agency recommended in that the use of the by mouth but not the IV form of moxifloxacin be restricted to infections in which other antibacterial agents cannot be used or have failed. The initial approval by the FDA December [14] encompassed these indications:.
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Thus, in addition to adequate drainage, empirical coverage with broad-spectrum antimicrobials is central to the management of such abscesses and an understanding of pharmacokinetic properties can be valuable when selecting antimicrobial agents. The present study examined the penetration of the fluoroquinolone antimicrobial moxifloxacin into abdominal abscess fluid in patients with an intra-abdominal abscess. Eight patients with CT or ultrasound evidence of a localized intra-abdominal abscess requiring interventional drainage without signs of generalized peritonitis were considered suitable candidates for pharmacokinetic analysis.
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