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Vulva pagets disease recurrence in rectum

Vulvar Paget's disease is very rare malignancy originating in vulvar apocrine-gland-bearing skin cells or as a manifestation of adjacent primary anal, rectal or bladder adenocarcinoma. Vulvar Paget's disease is most commonly seen in postmenopausal Caucasian females and appears clinically as red, eczematous and pruriginous — and sometimes painful — lesions. In most cases it is an intraepidermal adenocarcinoma in which tumor cells involve the epidermis and sometimes the underlying skin appendage, but sometimes there is focal dermal invasion. Probably because of its multicentric nature, Paget's disease has a chronic and relapsing course. Surgery has been the treatment of choice, but disease frequently extends far from the visible lesion and surgical margins are frequently positive.
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Extramammary Perianal Paget's Disease

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Clinical treatment of vulvar Paget's disease: a case report

Surgical Case Reports. December , Cite as. Anorectal carcinoma with pagetoid spread is even rarer. She has since undergone two reoperations for local rectal cancer recurrence. Then, warts frequently appeared on the vulva on several occasions. She underwent perineal tumor resection, and the final histological diagnosis was rectal cancer recurrence with pagetoid spread. The resected stump was positive for cancer cells, and tumor progression was rapid.
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Clinical treatment of vulvar Paget's disease: a case report

The disease can be classified as being either primary or secondary depending on the presence or absence of associated malignancies. If caught early and treated, prognosis is generally good. Primary EMPD is of cutaneous origins and is found within the epidermis or the underlying apocrine glands. The secondary form results due to an underlying adenocarcinoma spreading to the epidermis.
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Perianal Paget's disease is a rare malignancy. It is rarely isolated and often associated with an underlying adenocarcinoma. It usually presents with anal itchiness and discomfort and can be misdiagnosed as hemorrhoids.
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